FPL (A*STAR)

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The Functional Proteomics Laboratory at A*STAR is a high-profile group with a unique portfolio. It gathers broad expertise from diverse fields including biochemistry, immunology, cell biology and mass spectrometry. FPL lab’s long-term research interests are focused on the integration of cell biology and immunology with quantitative mass spectrometry-based proteomics.

FPL’s expertise includes multi-omic approaches in precision medicine for personalised therapies, antigen identification pipelines development, body fluid biomarker discovery, clinical proteomics and drug target deconvolution.

Key Capabilities

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EXPERT STAFF
The Functional Proteomics Laboratory team has unique expertise in drug discovery target deconvolution, protein/tissue/fluid biomarker identifications and cell biology bioID. The lab’s advanced mass spectrometry services include antigen identification, antibody specificity and characterization, and targeted proteomics validation (MRM, PRM).
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ADVANCED MASS SPECTROMETRY
- Drug discovery target deconvolution
- Proteins/tissue fluids: biomarkers identification
- Cell Biology
- Antigen identifications
- Antibody specificity characterisation
-Targeted proteomics validation

Core Expertise

  • Biomarker discovery (membrane proteome analysis, secretome analysis, etc.)
  • Large scale protein identification experiments (ligand identification)
  • Quantitative proteomics (SILAC, TMT, iTRAQ, di-Methyl)
  • Quantitative identification of interacting proteins (protein complexes analysis)
  • Post-translational modification analysis
  • Signaling networks analysis
  • DNA-, RNA- protein interactions
  • Lipids-protein interactions
  • Recombinant proteins/antibodies quality check
  • MHC presented peptides identification
  • Targeted proteomics PRMs (parallel reaction monitoring)

STAFF PERSONNEL/TEAM



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Contact Information

Address

Functional Proteomics Laboratory (FPL),

Institute of Molecular and Cell Biology (IMCB),

61 Biopolis Drive, Proteos #07-02, Singapore 138673

Contact point

Radoslaw Mikolaj Sobota

+65 6586 9646

TECHNOLOGY PLATFORM