This study investigated how cells precisely maintain their numbers in tissues, particularly after cell death. Results showed that when a cell dies, a protein called YAP helps to determine which neighboring cells will divide to replace it. This is influenced by factors like the size of the neighboring cells’ nuclei and how much mechanical force they experience. The study highlights the role of mechanical forces in tissue maintenance and regeneration.
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1Mechanobiology Institute, National University of Singapore, Singapore. 2Institute for Integrated Cell-Material Sciences, Kyoto University, Japan. 3Physico Chimie Curie, Institut Curie, France. 4Universite Paris Cite, Institut Jacques Monod, France. 5Department of Biological Sciences, National University of Singapore, Singapore.
